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Phthalates, non-phthalate plasticizers and bisphenols in Swedish preschool dust in relation to children’s exposure

Children are exposed to a wide range of chemicals in their everyday environments, including the preschool. In this study, the authors evaluated the levels of phthalates, non-phthalate plasticisers and bisphenols in dust from 100 Swedish preschools and identified important exposure factors in the indoor environment. In addition, children’s total exposure to these chemicals was […]

Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signalling

Several lines of evidence suggest that exposures to Endocrine Disrupting Chemicals (EDCs) such as pesticides increase the risks of neuropsychiatric disorders. Despite extended residual persistence of dichlorodiphenyltrichloroethane (DDT) in the environment, the mechanisms of perinatal actions of DDT that could account for adult-onset of depression are largely unknown. This study demonstrated the isomer-specific induction […]

A systematic review of the evidence for acute tolerance to alcohol – the “Mellanby effect”

This study reviewed the evidence for “the Mellanby effect”, that is, whether the response to a given blood alcohol concentration (BAC) is more marked when BAC is rising than at the same concentration when BAC is falling. The authors systematically searched the databases EMBASE, Medline, and Scopus up to and including December 2016 using […]

Asbestos ingestion and gastrointestinal cancer: a possible underestimated hazard

The presence of asbestos fibres (AFs) in drinking water could be linked with gastrointestinal cancers. However, it is not regulated in several countries due to conflicting evidence. Some reports mainly associated AF ingestion with gastric and colorectal cancer. Experimental evidence suggested a role for timing and extent of exposure, and showed that ingested AFs […]

Quantifying Hormone Disruptors with an Engineered Bacterial Biosensor

Endocrine disrupting compounds are found in increasing amounts in our environment, originating from pesticides, plasticisers, and pharmaceuticals, among other sources. Although the full impact of these compounds is still under study, they have already been implicated in diseases such as obesity, diabetes, and cancer. The list of chemicals that disrupt normal hormone function is […]

Occupational exposure and respiratory health problems among nutmeg production workers in Grenada, the Caribbean.

The nutmeg industry is a major contributor to the Grenadian economy. However, workers in the industry face many environmental and occupational health risks. The goal of this study was to investigate respiratory health problems and possible related occupational exposures among nutmeg production workers. A questionnaire, spirometry and allergen skin-prick test was given to 92 […]

The Diacetyl-exposed Human Airway Epithelial Secretome: New Insights Into Flavouring Induced Airways Disease

Bronchiolitis obliterans (BO) is an increasingly important lung disease characterised by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavouring ingredient diacetyl, commonly used to impart a buttery flavour to microwave popcorn, has been associated with BO development. In the occupational setting, diacetyl vapour is first encountered by […]

Toward a Comprehensive Hypothesis of Chronic Interstitial Nephritis in Agricultural Communities

Over the past 20 years, there has been an increase in chronic interstitial nephritis in agricultural communities (CINAC) not associated with traditional risk factors. This disease has become an important public health problem and is observed in several countries in Central America and Asia. CINAC predominantly affects young male farmers between the third and […]

Assessment of Personal Airborne Exposures and Surface Contamination from X-ray Vaporisation of Beryllium Targets at the National Ignition Facility

This study presents air and surface sampling data collected over the first two years since beryllium was introduced as a target material at the National Ignition Facility. Over this time, 101 experiments with beryllium-containing targets were executed. The data provides an assessment of current conditions in the facility and a baseline for future impacts […]