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Acute effect of air pollutants (carbon monoxide and ozone) on myocardial infarction mortality in Ningbo

In this study, the authors explored the effect of carbon monoxide (CO) and ozone (O(3)) in the air on the myocardial infarction mortality in Ningbo, Zhejiang province, China, from 2011 to 2015. The data of daily air quality surveillance and the causes of deaths in Ningbo from 1 January 2011 to 31 December 2015 […]

Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands

Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced forms of SCLE are analogous in their clinical, serological and histological features. Drug-induced SCLE has […]

Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis

Persistent presence of perfluoroalkyl acids (PFAAs) in the environment is due to their extensive use in industrial and consumer products, and their slow decay. Biochemical tests in rodent demonstrated that these chemicals are potent modifiers of lipid metabolism and cause hepatocellular steatosis. However, the molecular mechanism of PFAAs interference with lipid metabolism remains to […]

Biological effects of new-generation dialkyl phosphinate flame retardants and their hydrolysates in BALB/C mice

Aluminium methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminium diethylphosphinate (ADEP), and aluminium methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industrial markets, but their ecologic risk has been reported rarely. By exposing male BALB/c mice to DPs and dialkyl phosphinic acids, the authors studied […]

Toxicological risk at workplace and toxicity as Life Cycle Assessment impact category: Substitution of solvents as an example

Substitution of hazardous substances against less hazardous ones is a central requirement of the European Chemical Regulation REACH (European Regulation 1907/2006/EC). Hazardous substances emitted from products may not only affect the worker; drift off and distribution in the environment may finally result in exposure of the general population. This potential threat to health is […]

An expanded conceptual framework for solution-focused management of chemical pollution in European waters

This study describes a conceptual framework for solutions-focused management of chemical contaminants built on novel and systematic approaches for identifying, quantifying and reducing risks of these substances. The conceptual framework was developed in interaction with stakeholders representing relevant authorities and organisations responsible for managing environmental quality of water bodies. Stakeholder needs were compiled via […]

A thiourea-functionalised metal-organic macrocycle for the catalysis of Michael additions and prominent size-selective effect

In this study, a discrete tetranuclear thiourea-based metal-organic macrocycle (MOM) with a large size was constructed by a well-designed organic ligand and nickel(ii) ions via self-assembly. Incorporating thiourea groups as hydrogen-bond donors into a metal-organic complex system leads to a new approach for synthesising functionalised heterogeneous catalysts, as this not only introduces coordination sites […]

Simultaneously determination of bisphenol A and its alternatives in sediment by ultrasound-assisted and solid phase extractions followed by derivatisation using GC-MS

Bisphenol analogues are a group of chemicals which are being widely applied in industrial and household products owing to regulations on bisphenol A (BPA) in many countries. In this study, an analytical method, including extraction from complex environmental matrices, clean-up using solid phase extraction (SPE) and following-up derivatisation prior to gas chromatography coupled with […]

Discovery and characterisation of field resistance to organophosphorus chemicals in a major mite pest, Halotydeus destructor

The redlegged earth mite (Halotydeus destructor) is an agricultural pest in Australia that attacks a wide variety of crops and pasture species. Chemicals remain an important part of control strategies for H. destructor, despite the existence of resistance to pyrethroid insecticides in this species. Recent chemical control failures involving a second insecticide class, organophosphates, […]

Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52

Manganese is essential to life, and humans typically absorb sufficient quantities of this element from a normal healthy diet; however, chronic, elevated ingestion or inhalation of manganese can be neurotoxic, potentially leading to manganism. Although imaging of large amounts of accumulated Mn(II) is possible by MRI, quantitative measurement of the biodistribution of manganese, particularly […]