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International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

Although regulatory requirements for carcinogenicity testing of chemicals vary according to product sector and regulatory jurisdiction, the standard approach starts with a battery of genotoxicity tests. If any of the in vivo genotoxicity tests are positive, a lifetime rodent cancer bioassay may be requested, which allows the detection of non-genotoxic carcinogens (NGTxC). However, under […]

Mercury poisoning caused by Chinese folk prescription (CFP): A case report and analysis of both CFP and quackery

There is evidence of mercury in some Chinese folk prescriptions (CFP)s in China. In this study, the authors report a case of a 35-year-old rural woman, who took almost 35?g of Hg2O orally to treat her itchy skin followed a folk prescription of an unlicensed practitioners engaging in quackery (UPEQ), which lead to dark […]

Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants

There is a growing body of evidence that persistent organic pollutants (POPs) may increase the risk for cardiovascular disease (CVD), but the mechanisms remain unclear. High-density lipoprotein (HDL) acts protective against CVD by different processes, and we have earlier found that HDL from subjects with CVD contains higher levels of POPs than healthy controls. […]

Sex and genetic differences in the effects of acute diesel exhaust exposure on inflammation and oxidative stress in mouse brain

In addition to increased morbidity and mortality caused by respiratory and cardiovascular diseases, air pollution may also contribute to central nervous system (CNS) diseases. Traffic-related air pollution is a major contributor to global air pollution, and diesel exhaust (DE) is its most important component. DE contains more than 40 toxic air pollutants and is […]

Effects of structurally different noncoplanar and coplanar PCBs on HELF cell proliferation, cell cycle, and potential molecular mechanisms

Polychlorinated biphenyls (PCBs) are a group of chemicals that persist in the environment, indoors, and humans. Lung exposure to airborne and food contaminants, such as PCBs, may cause possible lung disorders, such as cancer. In the present study, the authors investigated the effects of structurally different lower chlorinated (?4Cl), noncoplanar PCB40, and coplanar PCB77 […]

Biopersistence and Translocation to Extrapulmonary Organs of Titanium Dioxide Nanoparticles after Subacute Inhalation Exposure to Aerosol in Adult and Elderly Rats

The increasing industrial use of nanoparticles (NPs) has raised concerns about their impact on human health. Since aging and exposure to environmental factors are linked to the risk for developing pathologies, the authors address the question of TiO2 NPs toxicokinetics in the context of a realistic occupational exposure. They report the biodistribution of titanium […]

Behavioural effect of low-dose BPA on male zebrafish: Tuning of male mating competition and female mating preference during courtship process

The ubiquity of environmental pollution by endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) is progressively considered as a major threat to aquatic ecosystems worldwide. Numerous toxicological studies have proved that BPA are hazardous to aquatic environment, along with alterations in the development and physiology of aquatic vertebrates. However, generally, there is a […]

Determining time-weighted average concentrations of nitrate and ammonium in freshwaters using DGT with ion exchange membrane-based binding layers

In this study, commercially-available AMI-7001 anion exchange and CMI-7000 cation exchange membranes were utilised as binding layers for DGT measurements of NO3-N and NH4-N in freshwaters. These ion exchange membranes are easier to prepare and handle than DGT binding layers consisting of hydrogels cast with ion exchange resins. The membranes showed good uptake and […]

Trophic dilution of cyclic volatile methylsiloxanes (cVMS) in the pelagic marine food web of Tokyo Bay, Japan

Bioaccumulation and trophic transfer of cyclic volatile methylsiloxanes (cVMS), specifically octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), were evaluated in the pelagic marine food web of Tokyo Bay, Japan. Polychlorinated biphenyl (PCB) congeners that are “legacy” chemicals known to bioaccumulate in aquatic organisms and biomagnify across aquatic food webs were used as a benchmark […]

Using change-point models to estimate empirical critical loads for nitrogen in mountain ecosystems

To protect ecosystems and their services, the critical load concept has been implemented under the framework of the Convention on Long-range Transboundary Air Pollution (UNECE) to develop effects-oriented air pollution abatement strategies. Critical loads are thresholds below which damaging effects on sensitive habitats do not occur according to current knowledge. In this study, the […]