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WHO publishes list of bacteria for which new antibiotics are urgently needed

The World Health Organization (WHO) recently published its first ever list of antibiotic-resistant “priority pathogens” – a catalogue of 12 families of bacteria that pose the greatest threat to human health. The list was drawn up in a bid to guide and promote research and development (R&D) of new antibiotics, as part of WHO’s […]

Cytotoxicity and molecular effects of biocidal disinfectants (quaternary ammonia, glutaraldehyde, poly(hexamethylene biguanide) hydrochloride PHMB) and their mixtures in vitro and in zebrafish eleuthero-embryos

Frequently used biocidal disinfectants, including quaternary ammonium compounds (QAC), glutaraldehyde and poly(hexamethylene biguanide) hydrochloride (PHMB), occur in the aquatic environment but their potential effects in fish are poorly known, in particular when occurring as mixtures. To investigate their joint activity, the authors assessed the cytotoxicity of three QACs (BAC, barquat and benzalkonium chloride), glutaraldehyde […]

Are antifouling paint particles a continuous source of toxic chemicals to the marine environment?

Antifouling paint particles (APPs) are generated during periodical maintenance of boat hulls. Chemical composition and toxicity (either chronic or acute) of APPs found in the sediment was evaluated using the epibenthic copepod Nitokra sp. The APPs analysed showed the presence of high levels of metals such as Cu (234,247±268?gg(-1)), Zn (112,404±845?gg(-1)) and the booster […]

Evaluating the environmental hazard of industrial chemicals from data collected during the REACH registration process

Registration dossiers for 11,678 industrial chemicals were retrieved from the database of the European Chemicals Agency, of which 3566 provided a numerical entry for the corresponding predicted no effect concentration for the freshwater environment (PNEC). A distribution-based examination of 2244 of these entries reveals that the average PNEC of an industrial chemical in Europe […]

EFSA panel clears fatty alkanamides for FCMs

A European Food Safety Authority (EFSA) scientific panel has cleared the mixture of methyl-branched and linear C14–C18 alkanamides derived from fatty acids for use in food contact materials (FCMs) in a published opinion. The substance is used in plastics, such as polyethylenes, as a ‘slip’ or ‘release’ agent. The Food Contact Materials, Enzymes, Flavourings […]

EU Biocides Regulation 528/2012 (EU BPR) – ECHA Public consultations on five biocidal active substances as potential candidates for substitution

Under the EU Biocides Regulation 528/2012 (EU BPR), if the evaluating Competent Authority concludes in its evaluation that an active substance meets the criteria for substitution of Article 10 (1) of EU BPR, before submitting its opinion to the Commission on the approval or renewal of the approval of an active substance, the European […]

EPA to pull back on fuel-efficiency standards for cars, trucks in future model years

The United States Environmental Protection Agency plans to announce its intent to withdraw final determination on strict fuel-efficiency standards for future cars and light trucks, the latest signal by the Trump administration that it is charting a new course on climate change. Two associations representing the world’s biggest automakers last week asked EPA Administrator […]

DEP backs water pollution bill

Department of Environmental Protection Deputy Secretary Scott Mandirola spoke before the state Senate Finance Committee recently about the agency’s support of a bill to change the stream-flow figures used to calculate permit discharge limits. The state Department of Environmental Protection supports the House-passed legislation that would allow increased discharges of toxic chemicals into West […]

Canada amends CEPA 1999 Export of Substances on the Export Control List Regulations

On 22 February 2017, the Canadian Environmental Protection Act 1999 (CEPA 1999) Export of Substances on the Export Control List Regulations was amended as per SOR/2017-11. The Export of Substances on the Export Control List Regulations impose controls on the export of substances listed on the Export Control List (ECL). The Regulations enable Canada […]

How to consider a read-across approach for multi-constituent and UVCB substances

A new document on using read-across for multi-constituent and UVCB (unknown or variable composition, complex reaction products or biological materials) substances describes key issues for assessing and addressing the complexity of read-across approaches for these substances. Furthermore, it contains example model cases to illustrate this complexity. Further information is available at: Read-across assessment framework […]