Insecticide toxic effects and blood biochemical alterations in occupationally exposed individuals in Punjab, Pakistan

//Insecticide toxic effects and blood biochemical alterations in occupationally exposed individuals in Punjab, Pakistan

Biomonitoring of people exposed to hazardous materials provides opportunities for early identification of several diseases, particularly in those individuals who are constantly exposed to pesticides, such as pesticide operators and workers in pesticide manufacturing industry. However, data on this hot topic are limited in Pakistan. In this study, insecticide toxic effects and biochemical alterations (i.e., damage in DNA and enzyme activity) were studied in blood samples of occupationally exposed individuals from Punjab, Pakistan. Eight out of twenty-seven blood samples (29.6%) of the pesticide operators were found positive in five insecticides, with the maximum concentration found for chlorpyrifos-methyl (0.039??g/mL). Eleven out of twenty-seven blood samples (40.7%) of the pesticide industry workers were found positive in eight insecticides, with the maximum concentration found for endosulfan (0.051??g/mL). Comet tail length was 16.88?±?4.57??m in pesticide industry workers and 16.33?±?3.78??m in pesticide operators, which were significantly higher (P??0.05) in exposed individuals, whereas values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) concentration were significantly higher (P?

Authors: Hayat K, Afzal M, Aqueel MA, Ali S, Saeed MF, Qureshi AK, Ullah MI, Khan QM, Naseem MT, Ashfaq U, Damalas CA. ; Full Source: Science of the Total Environment. 2019 Mar 10; 655:102-111. doi: 10.1016/j.scitotenv.2018.11.175. Epub 2018 Nov 13.