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A fugacity model assessment of ibuprofen, diclofenac, carbamazepine, and their transformation product concentrations in an aquatic environment

An updated version of FATEMOD, a multimedia fugacity model for environmental fate of organic chemicals, was set up to assess environmental behaviour of three pharmaceuticals in northern Lake Päijänne, Finland. Concentrations of ibuprofen, diclofenac, and carbamazepine were estimated at various depths at two sites: near a wastewater treatment plant and 3.5 km downstream the plant.

A fugacity model assessment of ibuprofen, diclofenac, carbamazepine, and their transformation product concentrations in an aquatic environment 2019-02-21T09:47:36+00:00

Profiles, variability, and predictors of urinary benzotriazoles and benzothiazoles in pregnant women from Wuhan, China

Benzotriazoles (BTRs) and benzthiazoles (BTHs) are emerging contaminants with high production volume worldwide, which exhibit potential health risk to human. To date, little is known about the exposure of BTRs and BTHs (BTs) on human, especially in the context of pregnancy. In the present study, the authors aimed to characterise the exposure profiles, temporal variability,

Profiles, variability, and predictors of urinary benzotriazoles and benzothiazoles in pregnant women from Wuhan, China 2019-02-21T09:47:36+00:00

Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos

Macrolide antibiotics (MALs) are widely used for both human and animal health. Most MALs and their metabolites transfer into aquatic organisms and environment resulting in violent consequences. Previous studies show that MALs cause cardiotoxicity in humans and mammals. However, the potential risk of these chemicals in aquatic organisms remains unclear. In the present study, the

Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos 2019-02-21T09:47:36+00:00

Different exposure profile of heavy metal and health risk between residents near a Pb-Zn mine and a Mn mine in Huayuan county, South China

Heavy metal contamination of environmental media in mining area is a global major concern because of its potential threat for human health through food chain. However, the comparison of exposure level and health risk is scarce among people living in the vicinity of mining area with different pollution source. In this study, the concentrations of

Different exposure profile of heavy metal and health risk between residents near a Pb-Zn mine and a Mn mine in Huayuan county, South China 2019-02-21T09:47:36+00:00

Cytological Effects of Bleaching Agent (Quneex) on Plant Cells and Plant DNA

There have been a number of reported drawbacks and efficacy issues regarding the use of bleaching agents in the plant industry. This study was conducted to determine the cytological effects of the bleaching agent (Quneex) on the plant cells and plant DNA using the Allium cepa assay. In the study, sixteen root meristems of A.

Cytological Effects of Bleaching Agent (Quneex) on Plant Cells and Plant DNA 2019-02-21T09:47:36+00:00

Bidirectional Association between Non-alcoholic Fatty Liver Disease and Gallstone Disease: A Cohort Study

Non-alcoholic fatty liver disease (NAFLD) and gallstone disease (GD) are often found to coexist but the sequential relationship of NAFLD and GD to each other remains controversial. The authors prospectively evaluated the bidirectional relationship of non-alcoholic fatty liver disease with gallstone disease. A cohort study was performed on Korean adults who underwent a health check-up

Bidirectional Association between Non-alcoholic Fatty Liver Disease and Gallstone Disease: A Cohort Study 2019-02-21T09:47:36+00:00

Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents

Anti-tumour activity studies were carried out on the HCT-116, PC3, MCF-7, A549, ?562, NCI-?929, Jurkat, THP-1, RPMI8228 tumour cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumour cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116,

Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents 2019-02-21T09:47:36+00:00

Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract

Epidemiological studies suggest tobacco consumption as a probable environmental factor for a variety of congenital anomalies, including low bone mass and increased fracture risk. Despite intensive public health initiatives to publicise the detrimental effects of tobacco use during pregnancy, approximately 10-20% of women in the United States still consume tobacco during pregnancy, some opting for

Video-based kinetic analysis of calcification in live osteogenic human embryonic stem cell cultures reveals the developmentally toxic effect of Snus tobacco extract 2019-02-21T09:47:36+00:00

UK clinical experience up to 52?weeks with linaclotide for irritable bowel syndrome with constipation

Linaclotide, a guanylate cyclase C agonist, has been shown in clinical trials to improve symptoms of irritable bowel syndrome with constipation (IBS-C). In this study, data from a real-world study of linaclotide in the UK are reported. This 1-year, multicentre, prospective, observational study in the UK enrolled patients aged 18?years and over initiating linaclotide for

UK clinical experience up to 52?weeks with linaclotide for irritable bowel syndrome with constipation 2019-02-21T09:47:36+00:00

BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance

The outcome of patients affected by mantle cell lymphoma (MCL) has improved in recent years, but there is still a need for novel treatment strategies for these patients. Human cancers, including MCL, present recurrent alterations in genes that encode transcription machinery proteins and of proteins involved in regulating chromatin structure, providing the rationale to pharmacologically

BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance 2019-02-21T09:47:36+00:00